- - 2025 NFL Week 16 odds, betting: Full list of Week 16 spreads

Ben Fawkes December 15, 2025 at 8:24 AM

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The 2025-26 NFL regular season is heading into the stretch run, and Week 15 saw the Kansas City Chiefs officially run out of time to make the postseason, after a 16-13 loss to the Los Angeles Chargers on Sunday. Patrick Mahomes also tore his ACL to add injury to insult for Kansas City.

It's never too early to look ahead to next week, though, and sportsbooks have already posted lines for every matchup.

Here are the odds for every Week 16 NFL game at BetMGM:

Thursday

Los Angeles Rams (-1.5, 44.5) at Seattle Seahawks

[Check out all of Yahoo's sports betting content here in our new betting hub]

Sunday

1 p.m. ET

Philadelphia Eagles (-6, 44.5) at Washington Commanders

Green Bay Packers (-1.5, 46.5) at Chicago Bears

Buffalo Bills (-10, 42.5) at Cleveland Browns

Los Angeles Chargers at Dallas Cowboys (-1.5, 49.5)

Kansas City Chiefs (-3.5, 37.5) at Tennessee Titans

Cincinnati Bengals at Miami Dolphins (-1.5, 50.5)

New York Jets at New Orleans Saints (-4.5, 40.5)

Minnesota Vikings (-2.5, 44.5) at New York Giants

Tampa Bay Buccaneers (-2.5, 45.5) at Carolina Panthers

4 p.m. ET

Jacksonville Jaguars at Denver Broncos (-3, 45.5)

Atlanta Falcons (-1.5, 46.5) at Arizona Cardinals

Pittsburgh Steelers at Detroit Lions (-7, 49.5)

Las Vegas Raiders at Houston Texans (-14.5, 37.5)

Sunday Night Football

New England Patriots at Baltimore Ravens (-2.5, 48.5)

Monday

San Francisco 49ers (-5.5, 46.5) at Indianapolis Colts

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Source: “AOL Sports”